Rheumatoid arthritis (RA) is an autoimmune disorder, which means that it is caused by an abnormality in the immune system. However, doctors are not sure what causes the immune system to attack their own tissues. In doing so, they determined which factors could contribute. This article will look at what causes rheumatoid arthritis.

What causes rheumatoid arthritis

Genetic factors.

There are certain genes that can play a small role in the development of RA, although not directly. In particular, researchers have identified several genetic markers that are known to control immune responses. They found that people who have one gene, in particular, HLA, can be 5 times more likely than RA than people without this gene.




However, not everyone with rheumatoid arthritis has the HLA gene, and not everyone with the rheumatoid arthritis gene has it. Therefore, studies show that these genes do not cause RA, but can make patients more vulnerable to its development.  Concomitant diseases of rheumatoid arthritis .

What causes rheumatoid arthritis

Environmental factors

What causes rheumatoid arthritis? There are several environmental factors that, combined with a genetic predisposition, put people at greater risk of developing RA. These include:

  • Bacteria and viruses.
  • Exposure to secondhand smoke.
  • Air pollution.
  • Toxic chemicals.

There are also a number of risks associated with environmental hazards, such as:

  • Mineral oils.
  • Silicate mineral (found in obsidian, granite, diorite, and sandstone).

Personal factors

Gender: Men and women are susceptible to rheumatoid arthritis, but the disease is much more common in women. In fact, 70 percent of people diagnosed with rheumatoid arthritis are women. This may be due to various hormonal factors that are involved in the development of RA. For example, changes in hormones (e.g., the use of certain contraceptives) have been associated with promoting the development of RA in people who are genetically susceptible or have been exposed to an initiating event. Symptoms of rheumatoid arthritis also usually improve or completely disappear during pregnancy, with frequent outbreaks more common after birth. Breastfeeding can also cause symptoms of RA, such as joint inflammation and low-grade fever.  Early signs of RA.

Age: RA can affect a person at any age, but it usually occurs in people aged 40-60. Some cases of juvenile rheumatoid arthritis do exist, so it’s important to be aware of this if the minor begins to experience symptoms associated with RA. Remember: early detection is the key to successfully treating this rheumatic disease.

What causes rheumatoid arthritis? Family History: Those with a family history of rheumatoid arthritis may be more likely to develop the disease itself.


Rheumatoid Arthritis Studies

In the past few years, a lot of research has been done to expand our understanding of the immune system and what makes it malfunctioning. New treatments have also been developed to help treat the disease. Some topics of intensive research include:

What are the genetic factors that predispose people to developing rheumatoid arthritis?

White blood cells, commonly known as T cells, are important for maintaining a healthy and properly functioning immune system. However, scientists have discovered variation-nucleotide polymorphism (SNP) in the gene that controls T cells. When the SNP gene is present, T cells try to repair joint disorders too quickly, causing inflammation and tissue damage associated with RA. The discovery of SNP can help determine the risk of people getting RA and can help explain why autoimmune diseases go on in families.  How to treat rheumatoid nodules ?

At conception, twins have the same set of genes. So why is only one twin developing RA?

GEMINI has only identical genomes at conception. After birth, developmental and environmental factors experienced during the growth stages differentiate the genomes. By studying the differences in the lives of twins, scientists can better determine where and why rheumatoid arthritis begins to develop. A method called a microchip is used to simultaneously study a large number of genes, as well as differences in cases where only one twin develops the disease. Thanks to these types of studies, the researchers were able to identify several genes that may be responsible for inflammation and bone erosion associated with RA.


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