Colchicine is a medicine that treats gout, extracted from plants of the Colchicum genus, a highly poisonous plant that has no antidote and is known to be toxic. It has been used for about 2000 years as an effective treatment for gout, and its modern use in pill form began in 1936. This article will look at the treatment of gout with colchicine and allopurinol. 

Treating gout with colchicine and allopurinol

How colchicine works .

Colchicine does not lower uric acid levels, but works to block inflammation caused by uric acid crystals. For pain relief, working very quickly, usually within 12 to 24 hours, slowing down the inflammation. Presumably this doesn’t work for everyone, but it has a good pain reduction success rate of about 75%, and colchicine should be taken within 12 hours of an attack for it to work most effectively. Be sure to drink 12 to 15 glasses of water daily while taking colchicine for the drug to work more effectively for you.

An important role in taking colchicine is the correct dosage, people have died from overdoses. The FDA recommended use is to take 1.2 mg and then 0.6 mg an hour later is enough for a day, just 1.8 mg during a gout attack. And to prevent gout attacks, it is recommended to take 0.6 mg once or twice a day for those over 16, with a maximum dose of 1.2 mg per day. Rheumatologists are now advising against taking unnecessary colchicine for long-term preventive treatment of gout. And on a daily basis, you should stop after taking 2 tablets, and you should stop after the first weeks of uric acid lowering therapy.  

What are the side effects

If you suffer from kidney disease, liver disease, bone marrow disease. As well as inflammatory bowel disease or low white blood cell counts, you should not take colchicine. And that usually means older people should refrain from taking it.

Diarrhea is usually a side effect. Other side effects include vomiting and nausea. It is very important to pay attention to how colchicine affects you personally, and allopurinol is the best drug for long-term treatment of gout. Also, allopurinol should be injected slowly after a gout attack because it can also trigger a gout attack in the beginning. Remember that colchicine stops the attack while allopurinol works to reduce the uric acid levels in your body. Colchicine is for limited use and allopurinol is for long-term use. Treatment of gout with colchicine and allopurinol.

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Gout and allopurinol

If you are suffering or have suffered from gout, you are faced with a prescription drug called allopurinol. It is used to treat gout and certain types of kidney stones and reduce uric acid levels. It blocks the production of uric acid. Remember that uric acid is a waste product usually found in the blood from the breakdown of purines and any excess sediment in the urine. It is the most common drug used for long-term treatment of gout or chronic gout. When excess uric acid causes crystals to form in the joints, which then leads to gout.

Allopurinol is usually prescribed in the range of 50 mg to 900 mg, depending apparently on the severity, and the total dosage of allopurinol gout is usually 300 mg per day. It is imperative that you have regular uric acid tests done during this treatment and that the prescribed dosage is right for you. The medicine is taken orally at the same time every day and after meals to reduce upset stomach. It is advisable to drink a full glass of water with each dose, and it is recommended that you drink at least 8 to 12 glasses of water per day. Of course, unless your doctor has ordered you to drink less fluids for other medical reasons.  

The weird part about using allopurinol is that it can increase the number of gout attacks at first, as this medication may take a few weeks to start working. In the meantime, your doctor will probably prescribe colchicine, ibuprofen, or nonsteroidal anti-inflammatory drugs (NSAIDs) to relieve your pain. Usually, the starting dose of allopurinol is low and is gradually increased. Ultimately, allopurinol will do its job and keep your uric acid at a healthy level and prevent further gout attacks.

A recent study that monitored 4,966 patients newly diagnosed with gout showed that allopurinol did not have cardiovascular benefits for patients with gout. In fact, of the two groups that took allopurinol and the other that did not take the drug, they found that the group taking allopurinol had a 20% risk of cardiovascular disease.  

What are the side effects of allopurinol

If you are allergic to a drug, you obviously shouldn’t take it. And if you are taking other medications, it is important to tell your doctor or pharmacist. Because very serious drug interactions can occur and cause you more harm. Upset stomach, nausea, diarrhea, or drowsiness may occur. A rash is one of the most common side effects and can occur even after months or years of treatment with allopurinol.

Rarer side effects that are more serious if they occur include the following: numbness or tingling of the hands, feet, itching or swelling, hypersensitivity reactions, light bleeding or bruising. As well as unusual tiredness, blood in the urine or pain when urinating, dark urine, signs of infection, vision changes, eye pain, loss of appetite, trouble breathing. Allopurinol is one of the drugs commonly known as Stevens-Johnson syndrome. And toxic epidermal necrolysis, two life-threatening dermatological conditions.

Store allopurinol at room temperature within 15-25 ° C away from light and moisture. And don’t store allopurinol in the bathroom. For treatment of gout with colchicine and allopurinol, 

Categories: Gout


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