Doctors prescribe Prednisolone for rheumatoid arthritis often, especially with severe symptoms and aggressive inflammation. With the development of additional autoimmune effects, the drug becomes assistant No. 1, which can greatly facilitate the patient’s life.
In most cases, patients take the drug in the form of tablets, but in especially difficult situations, doctors prescribe injections. Prednisone is widely used in the treatment of various arthritis, but it has some limitations and side effects that can become critical for certain groups of people. The medicine is especially dangerous for those who suffer from pathologies of the liver and kidneys.
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Description of substances and actions
The composition of Prednisolone contains synthetic hormones – replicas of cortisone and its derivative. In the human body with rheumatoid arthritis, there is no strong change in hormone production, but their increased dosages help relieve all the symptoms of the pathology.
The correct dose of Prednisolone in rheumatoid arthritis helps relieve inflammation, remove harmful substances, and prevent shock and allergic reactions. However, with prolonged use, impaired kidney, liver, and other massive side effects are possible.
Unpleasant symptoms after taking the medicine appear even if the doctor prescribes a limited dosage.
Tablets and injections are used to treat rheumatoid arthritis in case of exacerbation, as well as in the case of severe forms of the disease. Apply the drug to eliminate complicated types of pathology (vasculitis, for example).
A doctor should prescribe injections or Prednisolone tablets because with all the effectiveness, this substance often leads to severe side effects.
The effect of “prednisone” in arthritis
A glucocorticosteroid drug has several powerful effects, due to which it is prescribed for the treatment of arthritis:
- almost completely eliminates edema and inflammation during periods of exacerbation , prevents their progress for a long time;
- slows down the development of the disease, at the early start of treatment contributes to the regression of the disease (complete cure of arthritis is impossible);
- normalizes joint mobility – temporarily, for up to 6 months after the course;
- completely blocks or significantly limits autoimmune processes caused by arthritis;
- almost completely removes pain in the joints;
- increases the effectiveness of other anti-inflammatory drugs , including alternative recipes;
- slows down the process of joint destruction.
The effectiveness of therapy is maximized if the patient does not abuse the drug. Wrong reception “when necessary”, violation of courses lead to the fact that the body is insensitive to therapy.
This medicine has a persistent effect, is chemically synthesized and the appointment is carried out only by the attending physician. In this case, self-medication is not permissible.
Indications for the use of “Prednisolone”
To take “Prednisolone” for rheumatoid arthritis is indicated if the processes intensify or autoimmune reactions appear:
- painful sensations greatly increase until the loss of working capacity;
- inflammatory processes are accelerated, cover more tissues of the joint and muscles next to it;
- the risk of autoimmune reactions increases;
- the formation of complications with the threat of the formation of dangerous pathologies of a systemic nature (vasculitis of organs);
- the process of joint destruction accelerates, or all the symptom of the disease intensifies;
- serious disability up to disability, partial or complete immobility of the joints;
- long-term use of NSAIDs and the need for their replacement with other drugs.
But there are situations when taking Prednisolone in rheumatoid arthritis is completely contraindicated.
Prohibition of the use of the drug
Before taking “Prednisolone” for rheumatoid arthritis, you must make sure that there are no contraindications, as well as assess the possible risks. If contraindications are not observed, organ diseases that can be fatal can develop:
- the drug is prohibited in severe hypertension;
- you can not drink pills for diabetes;
- prohibited during pregnancy;
- do not take medicine for Itsenko-Cushing’s disease;
- inflammation of the kidneys and inner walls of the heart – a direct contraindication;
- you can not drink pills for psychoses and mental disorders;
- therapy is prohibited with circulatory failure 3 degrees;
- You can not drink tablets from the age of 80;
- an ulcer of the stomach and intestines – a complete ban on taking the drug;
- syphilis and tuberculosis;
- internal operations.
It is forbidden to take Prednisolone if a person has increased aggressiveness and excitability.
Rules for the use of tablets and injections
The doctor prescribes the regimen of Prednisolone for rheumatoid arthritis:
- low doses – from 5 to 15 mg per day;
- medium – from 20 to 40 mg per day;
- high – from 50 to 60 or more;
- pulse therapy – 1000 mg per day for a maximum of 3 days.
The very next day after the first use of the drug, a sharp decrease in symptoms is observed. With the introduction of injections, after 3-5 hours, relief of an acute attack occurs.
If you quickly reduce the dosage, withdrawal syndrome may occur.
With the withdrawal syndrome, symptoms of pathology sometimes intensify up to severe stiffness, arthralgia.
The amount of up to 15 mg per day is prescribed in order to eliminate inflammation, comparable therapy using non-steroidal agents is comparable. Minimal toxicity protects against severe side effects. If you take the drug at 7.5 mg per day, then within 2 years the rate of progression of the disease significantly decreases.
At the beginning of treatment, the drug is drunk 2-3 times a day, then you can take tablets in the morning 1 time. The duration of the course depends on the severity of the symptoms, sometimes a few months.
If you take the drug at 1-2 o’clock in the morning, then in the morning the painful feeling is reduced, the stiffness of the joints is reduced.
The use of pulse therapy
The maximum doses of Prednisolone are prescribed for exacerbation of the disease. They are administered intravenously when diluted in 150 ml of isotonic solution for 40 minutes. Such treatment guarantees the active deposition of the drug in the organs and brain.
When using pulse therapy, even in such small courses, the development of strong side effects is possible: hypertension, osteoporosis, problems with the adrenal glands. Reception is carried out only under the supervision of a specialist.
The appointment of shock doses of the drug should be strictly justified, but it is impossible to resort to therapy in this way regularly.
Side Effects of Prednisolone
Unpleasant reactions to taking the drug develop on the part of almost all body systems. They can be combined, or be an independent phenomenon:
- problems from the endocrine system, including menstrual irregularities and impaired adrenal function, diabetes, developmental delay in children;
- gastrointestinal tract problems: ulcer, gastritis, pancreatitis, as well as many other pathologies;
- metabolism: low nitrogen balance, calcium excretion, weight gain, increased sweating;
- heart: arrhythmia, diseases of different parts of the heart, hypertension.
Both the skeletal system and the central nervous system, as well as immunity, vision, and other organs, suffer when taking Prednisone.
“Prednisolone” is very effective in eliminating severe symptoms of arthritis. But its reception is a big risk for other organs.
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