Find out if Arthritis is hereditary, and if having a family member with arthritis can increase your risk. Is Arthritis a Hereditary disease

Know the genes involved in the development of arthritis and what other factors influence next.

1. Genetic predisposition of Rheumatoid Arthritis

Is Arthritis a Hereditary disease

There are 5 main genes related to the development of arthritis HLA-DRB1, PADI4, PTPN22, CCR6, and FCRL3

This was evidenced by finding these genes increased in people with arthritis compared to healthy people.

1.1. HLA-DRB1 gene

This is the main gene present in several ethnic groups that are associated with an increased risk of arthritis.

In each ethnic group, there are variants of this gene but it is found in both European and Asian populations and is greatly influenced by the environment and the presence of smoking. 

1.2. PADI4 gene

The PADI4 gene was found in the Japanese population and also in the Asian population. Greater expression and function of this gene could increase the risk of arthritis.

This gene has not been found in European populations, possibly because the smoking habit that would be decisive for gene expression is not frequent in this population.

1.3. PTPN22 gene

It is the most prevalent gene after HLA and has been associated with more than 20 different autoimmune diseases, especially in European populations.

This gene is rare to occur or may not exist in Asian and African populations.

1.4. CCR6 gene

This gene has been identified in Asian and European populations and would influence the activity of th17 cells that have an important role in the development of rheumatoid arthritis.

It is especially related to this type of arthritis and not to psoriasis in which another variant participates.

1.5. FCRL3 gene

This gene is common in the Japanese population with arthritis. It is related to the development of other diseases in European populations, but not of arthritis. Is Arthritis a Hereditary disease

2. Influential but not determining factor

According to the National University Hospital of Iceland, genes are not the only factor that triggers arthritis because genes interact with the environment.

Having a close relative with rheumatoid arthritis probably increases a person’s risk of developing the condition.

However, this is not decisive, that is, interaction with the environment, such as smoking or poor diet, may or may not promote the development of the disease.

According to the University of Colorado, environmental factors include, in addition to smoking, infections in different organs, hormones, work with exposure to silica or mineral oils in mining, upholstery, hairdressers.

Environmental factors increase the risk of arthritis but in turn, can increase gene expression in people with arthritis susceptibility.

Hormones and especially hormonal alterations of perimenopause make women 2 to 4 times more likely than men to develop arthritis.

Dietary factors such as high protein intake, red meat and, to a lesser extent, iron increase the risk of arthritis

On the other hand, vitamin D deficiency, antioxidants such as zinc, beta-cryptoxanthin, vitamin C, omega 3 protect against the development of arthritis. 

An increased risk of arthritis has been found in first-degree relatives who share many of these environmental factors.

However, a high prevalence has not been found in spouses or spouses of people with arthritis, which indicates that genetic factors also influence.

3. Arthritis genes and close relatives

According to the University of Tokyo, if you have a first-degree relative with arthritis disease, you are 3 times more likely to be diagnosed with arthritis.

The heritability of arthritis is estimated at approximately 60%. This states that there are genetic factors that increase susceptibility to arthritis.

A link between arthritis and genetics among twins has been identified, which share 100% of the genes, so they are more likely to be diagnosed with arthritis.

In twins, the risk of arthritis was found at 15% while in siblings it was reduced to between 5 to 8%.

A high risk of arthritis was also found among first and second degree relatives, in addition to siblings, for uncles of about 2%.

In turn, it has been proven that mothers are more likely than fathers to increase susceptibility to arthritis in their children.

4. Genes and arthritis activity

Is Arthritis a Hereditary disease

The most studied gene to date, HLA-DRB1 has a greater effect on the severity of arthritis.

In the Japanese population, it was shown that PADI4 is associated with a rapid progression of damage evidenced by radiographs.

According to Swedish University, certain loci, which indicate the position of the chromosomes that form the genes are associated with the severity of arthritis and joint erosion.

Arthritis can be triggered in a loci and then others that influence the progression of the disease.

In other words, the chronicity of arthritis is controlled by genes other than those associated with the origin of the disease.  

This is useful in the sense that knowing the genes that are activated in the disease process can identify the degree of progression of arthritis.

In turn, genes determine the response to medications and there are between 20 to 40% of arthritis patients who will not respond to one therapy and may respond to another.

Therefore, the genetic information of each patient could help avoid side effects and high medication costs.

Unfortunately, the prediction of genes in the severity of the disease or the response to medications is not completely absolute because environmental factors also influence.

That is why if you have family members with arthritis, you have an increased risk of arthritis but also the knowledge and opportunity to modify your lifestyle and reduce the risk of the disease.

Learn how you can prevent and treat arthritis in our blog, learn more about arthritis, its symptoms, diagnosis and natural treatment with home remedies and recipes. 


Is Arthritis a Hereditary disease

Categories: ARTHRITIS

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